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Isoflavone | Phytoestrogen

The terms Isoflavone and Phytoestrogen are often confused.  Phytoestrogen actually comprises at least three groups - isoflavones, lignans and coumestans.  The Isoflavone sub-group is a large one which includes many known components - genistein, daidzein, daidzin, biochanin, formononetin, equol, mononetin and many more.  Often no distinction is made between Phytoestrogen and Isoflavone, or the term Isoflavone may be used for the whole sub-group, or for its individual components, without its meaning being clear.

Tofupill is unlike any supplement that contains a few extracted isoflavones, eg genistein and daidzin.  It is naturally derived with a unique enzymatic process which ensures that the whole phytoestrogen family of compounds including the lignans and the coumestans, as found in tofu, remain in its naturally intact form.

Isoflavone may not help hot flashes - meta analysis

By Stephen Daniells
09/05/2006 - Isoflavone supplementation does not help alleviate hot flashes for postmenopausal women, says a new meta-analysis.
[Note - medically "postmenopausal" means having started the menopause and onwards.]

Effect of isoflavone on bone mass density
By Sanne Kreijkamp-Kaspers MD, PhD
Conclusion: This double-blind randomized trial does not support the hypothesis that the use of soy protein supplement containing isoflavones improves cognitive function, bone mineral density, or plasma lipids in healthy postmenopausal women when started at the age of 60 years or later.

Red clover-derived isoflavones and mammographic breast density: a double-blind, randomized, placebo-controlled trial [ISRCTN42940165]
By Charlotte Atkinson, Ruth ML Warren, Evis Sala, Mitch Dowsett, Alison M Dunning, Catherine S Healey, Shirley Runswick, Nicholas E Day and Sheila A Bingham
Hot flushes and menopausal symptoms: Interactions between treatment group and menopausal status for changes in menopausal symptom score and number of hot flushes were not statistically significant (P > 0.05). Among women who experienced hot flushes at either assessment period, or among women whose menopausal symptom score was greater than zero at either assessment period, there were no significant effects of treatment group on hot flushes or menopausal symptoms.

The above three studies do not apply to Tofupill which is not in the same category as Isoflavone based supplements as explained above.  Tofupill has been proven effective to help with the menopause.  Furthermore the recommended intake of 2 capsules per day has shown a positive effect on bone health in women from the perimenopause onwards.  Publication details of the main studies are shown on this website.

We would emphasise that the Tofupill trials are done to the high standards required by international medical journals and are approved by the Helsinki Committee (a regulatory body for trials).  These published studies on Tofupill make it the most well-proven of any menopausal supplement.  Further scientific information is available to doctors and other health practitioners.

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